Injections and tablets: 5 new solutions for weight loss

In addition to a nutritious diet and bodily train, medical doctors might prescribe drugs for those that are within the technique of dropping weight. And new medication, in injectable or capsule kind, promise to help in therapy, as they velocity up the metabolism, burn saved fats, cut back urge for food and management food-related feelings.

The major goal of some is the therapy of diabetes, however, as a result of they trigger weight loss, they’re broadly accepted by medical doctors. Therefore, specialists emphasize that these medicines needs to be used solely below the steerage of skilled professionals.

Medications for weight loss could be injectable. Credit: Shutterstock

Medicines containing a receptor known as GLP-1 have already been instructed by specialists due to their significance in weight loss. This receptor is a protein present in pancreatic cells and neurons that helps regulate blood sugar and launch insulin.

This ingredient helps launch hormones within the intestine after a meal and acts instantly on the mind to manage urge for food and thus, induce a sense of satiety. Now, new medication seem to extend the effectiveness of this molecule.

“When we discuss in regards to the progressive medication utilized by medical doctors, medication of the semaglutide and liraglutide class, selective stimulators of GLP-1, are more practical in controlling urge for food, as a result of they assist in the buildup of visceral fats and within the therapy of insulin. It doesn’t give resistance and rebound impact. These are well-managed medication, very viable for weight loss when correctly indicated. Today, they’re those I work with probably the most”, stated nutritionist Mariana Comerio.

The semaglutide Medicines like Rybelsus can be found on the oral market and are accepted by Anvisa (National Health Surveillance Agency). The drug, in capsule kind, have to be taken each day as per medical tips.

This treatment will increase satiety, reduces starvation all through the day and aids in weight loss. However, to realize outcomes with the usage of this product, it is usually necessary to keep up a balanced weight loss plan and train repeatedly.

Another drug with the identical lively ingredient is Ozempic, which is simply accepted in Brazil for the therapy of kind 2 diabetes. But specialists hope that quickly, a scientific examine on its actions within the therapy of weight problems will probably be performed and approved. For this use. However, it started to be prescribed “off label” by medical doctors. The medication is injectable and subsequently, is utilized with the assistance of a pen.

Substance Liraglutide is the primary anti-obesity drug of the incretin-mimetic class, often known as an agonist (stimulator) of the GLP-1 receptor. It is bought commercially below the identify Saxenda, additionally in injectable kind, and is permitted by Anvisa for use within the therapy of kind 2 diabetes and weight problems.

Saxenda was made out of the drug Victoza, which is used solely to manage kind 2 diabetes. With new research, the drug’s drugmaker, Novo Nordisk, has concluded that greater doses present higher weight loss ends in folks with weight problems. Saxenda was thus formulated with an adjustable dose for these sufferers.

Balance between meals and feelings

“What are the advantages of those medication? The affected person creates meals schooling. He learns to eat much less and compensate much less for his emotions in meals. He learns that it’s attainable to reside with much less meals and reside effectively”, Mariana reinforces.

Mariana Comerio

Dietitian

“Drugs take away the urge to eat. Over time, when the drug is withdrawn, the physique adapts to this decreased quantity of meals.”

Anvisa will not be but accepted, however guarantees a new period within the therapy of weight problems, Tirzepatida is one other drug within the record of new allies in opposition to weight problems.

It acts as two intestine hormones: GLP-1 and GIP, which collectively induce sturdy weight loss by way of totally different mechanisms, cerebral and gastrointestinal. The drug is given as a weekly subcutaneous injection.

Lilly Laboratories has already submitted a product registration request to Anvisa and is awaiting publication. Tirzepatida is predicted to be accepted by the center of subsequent yr.

Sabrina Ribeiro Franca

Endocrinologist

“This drug has a really important weight loss exercise and is totally different from others. Studies have proven a discount of as much as 25% of physique weight”

Contrave, a capsule remedy that treats meals compulsions, could be over-the-counter and bought at a pharmacy. It has two substances in its composition, bupropion and naltrexone, which act on the mind by decreasing and controlling urge for food, along with cravings for meals, thereby decreasing meals consumption. In addition, Contrave permits you to cut back waist circumference, stop diabetes or coronary heart illness.

Use with out medical recommendation might trigger pancreatic issues

Although Brazilians are used to self-medication, there are lots of dangers in the usage of weight loss medication with out authorization or medical recommendation, which may additionally make the affected person insulin dependent, that’s, somebody who wants insulin.

“Why do we are saying that medication want medical recommendation? Because there’s a danger of pancreatitis, which is the failure of the pancreas organ, which is necessary for the manufacturing of insulin, which causes the affected person to develop full pancreatitis and grow to be insulin-dependent diabetes”, highlighted nutritionist Mariana Comerio.

Additionally, utilizing it with out medical supervision may cause an individual to take the next dose than vital and trigger nausea, loss of urge for food and, in consequence, weak spot.

“It has a minimal dosage advice, however every affected person is particular person. So it’s vital to watch and information him, in order that he doesn’t really feel sick, not an image of constipation, which may occur”, warns Mariana.

She continues: “In addition, there are medication that cut back gastroparesis, which makes the bowel empty. If the drug will not be managed appropriately, hemorrhoids can develop. It is necessary for the affected person to grasp that the drug is a kick. The starting of high quality of life, however rigorously. “

For endocrinologist Sabrina Ribeiro Franca, it is usually vital to finish the unfairness in opposition to the usage of medication to deal with weight problems.

“It is important to eradicate the unfairness that medication can’t be used. Each affected person is particular person and throughout the technique of weight loss the physician will decide their path. Medicines, even when they’re costly, needs to be used responsibly.”

Learn extra about new drugs used for weight loss

Rybalsus is a diabetes pill that has revolutionized weight loss
Rybalsus is a diabetes drug, in capsule kind, that has led to innovation in weight loss. Credit: Disclosure
  • Rybelsus: This is the commerce identify of semaglutide and accepted by Anvisa (National Health Surveillance Agency). Oral medicines needs to be taken each day as per medical recommendation. Semaglutide comprises the GLP-1 receptor, a hormone launched by the intestine after a meal and which acts on receptors within the mind that regulate urge for food, satiety and urge for food.
  • This treatment will increase satiety, reduces starvation all through the day and aids in weight loss. However, to realize the outcomes of its use, it is usually necessary to keep up a balanced weight loss plan and train repeatedly. It is on the market in dosages of 3mg, 7mg and 14mg. It can solely be bought with a physician’s prescription.
  • unwanted side effects: chilly sweat, cool pale pores and skin, headache, quick heartbeat, feeling sick (nausea) or very hungry, imaginative and prescient modifications, drowsiness or weak spot, nervousness, nervousness or confusion, problem concentrating or tremors.
Saxenda, a diabetes drug that helps with weight loss
Saxenda, a diabetes drug that helps with weight loss. Credit: Reproduction/Novo Nordisk
  • Saxony: It is a medication within the type of an injection that acts on the midpoint between starvation and satiety, making an individual really feel much less hungry. In addition, one of many results of the drug is a change in style, which makes meals style much less nice. This drug could be present in pharmacies, bought solely with a physician’s prescription.
  • A field containing resolution for injection is 6mg/ml with three disposable pens.
  • Side results: The most frequent unwanted side effects of this drug are nausea, vomiting, diarrhea, constipation, indigestion, gastritis, stomach discomfort, stomach ache and burning, bloating, fuel, belching, dry mouth, weak spot, fatigue. Change in style.
Contrav is a drug used to treat obesity
Contrav is a drug used to deal with weight problems. Credit: Reproduction
  • opposition: It is a capsule resolution that helps folks affected by weight problems or obese to lose weight, as a result of it comprises two substances in its composition, bupropion and naltrexone, which act on the mind, cut back and management urge for food. Craving for meals. , which reduces meals consumption. The drug Amvisa has not too long ago been accepted.
  • Side results: The most typical, which can happen throughout therapy, are dry mouth, headache, dizziness, constipation or diarrhea, nausea, vomiting, insomnia, irritability, melancholy, nervousness, restlessness, muscle or joint ache.

The anti-obesity treatment will not be but accepted by Anvisa

Tirzepatide is used for weight loss and diabetes
Tirzepatide is used for weight loss and diabetes. Credit: Disclosure
  • Tirezepetide: It works by mimicking two intestine hormones: GLP-1 and GIP, which collectively induce sturdy weight loss by way of totally different mechanisms, each cerebral and gastrointestinal. The drug is given as a weekly subcutaneous injection.
  • Lilly Laboratories has already submitted a request for drug registration to Amvisa and is ready for the organ to be launched.
(*5*)
Ozempic is used for weight loss and diabetes. Credit: Reproduction
  • ozempic: It was accepted by Anvisa in August 2018 for the therapy of kind 2 diabetes solely. It comprises the identical lively ingredient as Rybelsus, semaglutide, however the drug is injectable.
  • Novo Nordisk, to deal with weight problems, was now indicated by medical doctors “off label” (outdoors the bundle leaflet), regardless of not being accepted by Anvisa or the manufacturing firm. It reduces insulin manufacturing and gastric emptying, slows digestion, will increase satiety. However, specialists warn that this and any drug could be prescribed provided that there may be scientific assist.


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